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1995 - 2004年德国髋部骨折发病率趋势:一项基于人群的研究。

Trend of hip fracture incidence in Germany 1995-2004: a population-based study.

作者信息

Icks A, Haastert B, Wildner M, Becker C, Meyer G

机构信息

Faculty of Public Health, Department of Epidemiology and International Public Health, School of Public Health, Bielefeld University, Bielefeld, Germany.

出版信息

Osteoporos Int. 2008 Aug;19(8):1139-45. doi: 10.1007/s00198-007-0534-6. Epub 2007 Dec 18.

Abstract

UNLABELLED

We analyzed hip fracture incidence trends in Germany 1995-2004, using national hospital discharge register. Crude incidences per 100,000 increased from 121.2 (95% CI 120.5-121.9) in 1995 to 140.9 (140.2-141.7) in 2004. Age-sex-adjusted annual incidence ratios showed a statistically significant, but only slight increase (1.01, p<0.01), compared to higher rises in the past. Trends differed markedly with sex, age, and regions.

INTRODUCTION

Data concerning actual trends of the hip fracture incidence and differences for sex, age, and region are limited. We analyzed hip fracture incidence trends in Germany 1995-2004, using the national hospital discharge register. Crude incidences per 100,000 increased from 121.2 (95% CI 120.5-121.9) in 1995 to 140.9 (140.2-141.7) in 2004. Age-sex-adjusted annual incidence ratios showed a statistically significant, but only slight increase (1.01, p<0.01), compared to higher rises in the past. Trends differed markedly with sex, age, and regions.

METHODS

Analysis of annual hip fracture incidences using the national hospital discharge register. Estimate of age-sex-adjusted changes was found by using Poisson regression (incidence rate ratios, IRR).

RESULTS

The number of patients with at least one hospital admission for hip fracture increased (1995: n=99,141; 2004: n=116,281). Crude incidences per 100,000 were 121.2 (95% confidence interval 120.5-121,9) and 140.9 (140.2-141.7), respectively. The age-sex-adjusted hip fracture incidence increased statistically significantly, but only slightly (IRR per year: 1.01; 1.00-1.01; IRR 1995-2004: 1.05, p<0.01). In men aged 40 years or older, incidences increased. In women, there was a tendency of a decrease up to 74 years of age, but also a significant increase in higher age groups. In people 0-39 years, the incidence declined markedly (IRR 1995-2004, men 0.74; 0.69-0.79, women 0.62; 0.55-0.69, both p<0.01). The increase was significantly higher in Eastern compared to Western Germany (interaction: p=0.002), and differences between East and West decreased.

CONCLUSIONS

In contrast to earlier years, the hip fracture incidence in Germany 1995-2004 increased only slightly, with a decline in younger people, but increases in older ages, particularly in men. Regional differences decreased.

摘要

未标注

我们利用全国医院出院登记数据,分析了1995 - 2004年德国髋部骨折发病率趋势。每10万人的粗发病率从1995年的121.2(95%可信区间120.5 - 121.9)增至2004年的140.9(140.2 - 141.7)。与过去较高的增长率相比,年龄 - 性别调整后的年发病率比值显示出有统计学意义但仅为轻微的增长(1.01,p<0.01)。趋势在性别、年龄和地区上有显著差异。

引言

关于髋部骨折发病率的实际趋势以及性别、年龄和地区差异的数据有限。我们利用全国医院出院登记数据,分析了1995 - 2004年德国髋部骨折发病率趋势。每10万人的粗发病率从1995年的121.2(95%可信区间120.5 - 121.9)增至2004年的140.9(140.2 - 141.7)。与过去较高的增长率相比,年龄 - 性别调整后的年发病率比值显示出有统计学意义但仅为轻微的增长(1.01,p<0.01)。趋势在性别、年龄和地区上有显著差异。

方法

利用全国医院出院登记数据对年度髋部骨折发病率进行分析。通过泊松回归(发病率比值,IRR)来估计年龄 - 性别调整后的变化。

结果

至少因髋部骨折入院一次的患者数量有所增加(1995年:n = 99,141;2004年:n = 116,281)。每10万人的粗发病率分别为121.2(95%置信区间120.5 - 121.9)和140.9(140.2 - 141.7)。年龄 - 性别调整后的髋部骨折发病率有统计学意义的显著增加,但增幅较小(每年的IRR:1.01;1.00 - 1.01;1995 - 2004年的IRR:1.05,p<0.01)。40岁及以上男性的发病率有所上升。在女性中,74岁及以下有下降趋势,但高龄组也有显著增加。0 - 39岁人群的发病率显著下降(1995 - 2004年的IRR,男性为0.74;0.69 - 0.79,女性为0.62;0.55 - 0.69,两者p<0.01)。与西德相比,东德的增幅明显更高(交互作用:p = 0.002),且东西部之间的差异有所减小。

结论

与早年相比,1995 - 2004年德国髋部骨折发病率仅略有增加,年轻人发病率下降,而老年人尤其是男性发病率上升。地区差异减小。

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