Lewis Rowena S, Ward Alister C
Cancer & Haematology Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, 3050, Australia.
Expert Rev Mol Diagn. 2008 Jan;8(1):73-82. doi: 10.1586/14737159.8.1.73.
The Jak-Stat-Socs pathway is an important component of cytokine receptor signaling. Not surprisingly, perturbation of this pathway is implicated in diseases of hematopoietic and immune origin, including leukemia, lymphoma and immune deficiencies. This review examines the role of a key component of this pathway, Stat5. This has been shown to be activated in a variety of leukemias and myeloproliferative disorders, including downstream of a range of key oncogenes where it has been shown to play an important role in mediating their effects. Therefore, Stat5 represents a useful pan-leukemia/myeloproliferative disorder diagnostic marker and key therapeutic end point, as well as representing an attractive therapeutic target for these disorders.
Jak-Stat-Socs信号通路是细胞因子受体信号传导的重要组成部分。毫不奇怪，该信号通路的紊乱与造血和免疫源性疾病有关，包括白血病、淋巴瘤和免疫缺陷。本综述探讨了该信号通路关键组成部分Stat5的作用。已证实在多种白血病和骨髓增殖性疾病中Stat5被激活，包括在一系列关键癌基因的下游，已表明它在介导这些癌基因的作用中发挥重要作用。因此，Stat5是一种有用的全白血病/骨髓增殖性疾病诊断标志物和关键治疗终点，也是这些疾病有吸引力的治疗靶点。
