Schauer J, Orschekowski H, Winkler J, Steiniger L
Klinik für Innere Medizin, Universität Leipzig.
Z Erkr Atmungsorgane. 1991;177(3):204-16.
Acute effects of Trapidil (Rocornal, Deutsches Hydrierwerk Rodleben) on pulmonary hemodynamics were studied in 47 patients. A marked decrease of pulmonary artery pressure, pulmonary vascular resistance and of right ventricular stroke work at rest and during exercise in different degrees of severity of pulmonary hypertension was shown. Especially the influence on stable pulmonary hypertension is of interest, but there was no statistical significance during exercise because of the small number of patients. Considerable objective or/and subjective side effects were not noticed. Possible multifactorial mechanisms of these effects including the left ventricular function and the role of prostaglandins are discussed. The effect of trapidil is compared with other investigated pulmonary vasodilators, such as nitrates and nifedipine. Because of hitherto there are no other studies with Rocornal in patients with COPD, further acute studies and placebo controlled long term studies with monitoring of pulmonary hemodynamic are necessary. Than it will be possible to clarify the role of trapidil in therapeutical concepts of pulmonary hypertension.
在47例患者中研究了曲匹地尔（Rocornal，德国罗德leben氢化工厂）对肺血流动力学的急性影响。结果显示，在不同严重程度的肺动脉高压患者中，静息和运动时肺动脉压、肺血管阻力及右心室搏功均有不同程度的显著降低。尤其对稳定型肺动脉高压的影响令人关注，但由于患者数量较少，运动时未显示出统计学意义。未观察到明显的客观或/和主观副作用。讨论了这些作用可能的多因素机制，包括左心室功能和前列腺素的作用。将曲匹地尔的作用与其他研究过的肺血管扩张剂如硝酸盐和硝苯地平进行了比较。由于目前尚无关于Rocornal治疗慢性阻塞性肺疾病（COPD）患者的其他研究，因此有必要进行进一步的急性研究以及监测肺血流动力学的安慰剂对照长期研究。这样才有可能阐明曲匹地尔在肺动脉高压治疗理念中的作用。
