Pérez M J, Martín R O, García D M, Rey J M Lozano, de la Cruz Lombardo J, Rodrigo López J M
Unidad de Hepatologia-Trasplante Hepático, Servicio de Aparato Digestivo, Hospital Universitario Carlos Haya, Malaga, Spain.
Transplant Proc. 2007 Dec;39(10):3498-9. doi: 10.1016/j.transproceed.2007.06.082.
Sirolimus is a powerful immunosuppressive drug initially used in kidney transplant patients but now increasingly employed in recipients of other types of solid organ transplants, such as liver, heart, lung, or pancreas. Sirolimus is indicated for rescue therapy and to reduce the toxic side effects of calcineurin inhibitors. However, its use has been associated with an uncommon but important pulmonary toxicity. Reports have described interstitial pneumonitis, bronchiolitis obliterans, organizing pneumonia, and alveolar proteinosis. We present the case of a liver transplant patient with interstitial pneumonitis associated with sirolimus.
西罗莫司是一种强效免疫抑制药物，最初用于肾移植患者，但现在越来越多地用于其他类型实体器官移植的受者，如肝、心、肺或胰腺移植受者。西罗莫司适用于挽救治疗，并减少钙调神经磷酸酶抑制剂的毒副作用。然而，其使用与一种罕见但重要的肺部毒性有关。报告描述了间质性肺炎、闭塞性细支气管炎、机化性肺炎和肺泡蛋白沉积症。我们报告一例肝移植患者发生与西罗莫司相关的间质性肺炎的病例。
Zotero 插件