肝移植患者的恶性高热：一例报告
Malignant hyperthermia in a liver transplant patient: a case report.
作者信息
Fernandes C R, Azevedo D M, Gomes J M, Gonçalves B P, Coelho G R, Vasconcelos J B, Garcia J H
机构信息
Surgery Department, Federal University of Ceará, Ceará, Brazil.
出版信息
Transplant Proc. 2007 Dec;39(10):3530-2. doi: 10.1016/j.transproceed.2007.09.036.
Malignant hyperthermia is an autosomal dominant disorder with incomplete penetrance and variable expression. This syndrome is characterized by a hypermetabolic response to all commonly used inhalational anesthetics and depolarizing muscle relaxants. It can happen during or after the anesthesia. We describe a case of malignant hyperthermia during orthotopic liver transplantation. Our patient was a 48-year-old man, born in Brazil but with European ascendance, who developed malignant hyperthermia associated with the use of isoflurane. He was treated with dantrolene, which caused hepatic graft dysfunction. It is important that transplant teams be able to recognize and treat this complication.
恶性高热是一种常染色体显性疾病，具有不完全显性和可变表达。该综合征的特征是对所有常用吸入麻醉剂和去极化肌肉松弛剂产生高代谢反应。它可发生在麻醉期间或之后。我们描述了一例原位肝移植期间发生恶性高热的病例。我们的患者是一名48岁男性，出生于巴西但有欧洲血统，在使用异氟烷时发生了恶性高热。他接受了丹曲林治疗，但这导致了肝移植功能障碍。移植团队能够识别和治疗这种并发症很重要。
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