低剂量丹曲林可有效治疗体温过高和高碳酸血症，且似乎不影响肝移植后同种异体移植物的恢复：病例报告。

Low-dose dantrolene is effective in treating hyperthermia and hypercapnia, and seems not to affect recovery of the allograft after liver transplantation: case report.

作者信息

Shih T-H, Chen K-H, Pao Y-Y, Yang S-C, Chen C-L, Huang C J, Wang C-H, Jawan B, Cheng K W, Yang C-H

机构信息

Department of Anesthesiology, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University, Taipei, Taiwan.

出版信息

Transplant Proc. 2010 Apr;42(3):858-60. doi: 10.1016/j.transproceed.2010.02.023.

DOI:10.1016/j.transproceed.2010.02.023

PMID:20430190

Abstract

Dantrolene is the drug of choice in treatment of malignant hyperthermia. However, dantrolene is hepatotoxic; thus prolonged use is not recommended in patients with active hepatic disease such as acute hepatitis or active cirrhosis because it may result in fatal hepatic failure. Use of dantrolene in a patient with end-stage liver disease undergoing liver transplantation (LTx) in whom suspected malignant hyperthermia developed has been reported rarely. Its effect on the liver allograft, which has sustained cold, warm, and reperfusion injuries, is currently unknown. We report a case in which low-dose dantrolene administered intravenously during LTx was effective in treating hyperthermia, hypercapnia, and hyperkalemia. Furthermore, its reported hepatotoxic effect seemed to not affect recovery of the allograft after LTx.

摘要

丹曲林是治疗恶性高热的首选药物。然而，丹曲林具有肝毒性；因此，对于患有活动性肝病（如急性肝炎或活动性肝硬化）的患者，不建议长期使用，因为这可能导致致命的肝衰竭。丹曲林在接受肝移植（LTx）的终末期肝病患者中使用，且该患者疑似发生恶性高热的情况鲜有报道。其对经受冷、热及再灌注损伤的肝脏移植器官的影响目前尚不清楚。我们报告了一例在肝移植手术期间静脉注射低剂量丹曲林有效治疗高热、高碳酸血症和高钾血症的病例。此外，其已报道的肝毒性作用似乎并未影响肝移植术后移植器官的恢复。