Woodruff Teresa K, Shea Lonnie D
Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Reprod Sci. 2007 Dec;14(8 Suppl):6-10. doi: 10.1177/1933719107309818.
Regulation of ovarian follicle development depends on endocrine- and paracrine-acting hormones, the 3-dimensional architecture of the follicle, and the physical rigidity of the surrounding tissue. These 3 forces are integrated throughout the life cycle of the follicle to ensure appropriate hormone secretion, differentiation of the somatic cells, and maturation of the oocyte. The process of in-follicle maturation provides a new tool for understanding ovarian follicle development under the influence of these factors.
卵巢卵泡发育的调节取决于内分泌和旁分泌作用的激素、卵泡的三维结构以及周围组织的物理硬度。在卵泡的整个生命周期中,这三种力量相互整合,以确保适当的激素分泌、体细胞的分化以及卵母细胞的成熟。卵泡内成熟过程为理解这些因素影响下的卵巢卵泡发育提供了一种新工具。