Holick Michael F, Biancuzzo Rachael M, Chen Tai C, Klein Ellen K, Young Azzie, Bibuld Douglass, Reitz Richard, Salameh Wael, Ameri Allen, Tannenbaum Andrew D
Department of Medicine, Boston University School of Medicine, 715 Albany Street, M-1013, Boston, Massachusetts 02118, USA.
J Clin Endocrinol Metab. 2008 Mar;93(3):677-81. doi: 10.1210/jc.2007-2308. Epub 2007 Dec 18.
Two reports suggested that vitamin D2 is less effective than vitamin D3 in maintaining vitamin D status.
Our objective was to determine whether vitamin D2 was less effective than vitamin D3 in maintaining serum 25-hydroxyvitamin D levels or increased the catabolism of 25-hydroxyvitamin D3.
This was a randomized, placebo-controlled, double-blinded study of healthy adults ages 18-84 yr who received placebo, 1000 IU vitamin D3, 1000 IU vitamin D2, or 500 IU vitamin D2 plus 500 IU vitamin D3 daily for 11 wk at the end of the winter.
Sixty percent of the healthy adults were vitamin D deficient at the start of the study. The circulating levels of 25-hydroxyvitamin D (mean+/-sd) increased to the same extent in the groups that received 1000 IU daily as vitamin D2 (baseline 16.9+/-10.5 ng/ml; 11 wk 26.8+/-9.6 ng/ml), vitamin D3 (baseline 19.6+/-11.1 ng/ml; 11 wk 28.9+/-11.0 ng/ml), or a combination of 500 IU vitamin D2 and 500 IU vitamin D3 (baseline 20.2+/-10.4 ng/ml; 11 wk 28.4+/-7.7 ng/ml). The 25-hydroxyvitamin D3 levels did not change in the group that received 1000 IU vitamin D2 daily. The 1000 IU dose of vitamin D2 or vitamin D3 did not raise 25-hydroxyvitamin D levels in vitamin D-deficient subjects above 30 ng/ml.
A 1000 IU dose of vitamin D2 daily was as effective as 1000 IU vitamin D3 in maintaining serum 25-hydroxyvitamin D levels and did not negatively influence serum 25-hydroxyvitamin D3 levels. Therefore, vitamin D2 is equally as effective as vitamin D3 in maintaining 25-hydroxyvitamin D status.
两份报告表明,在维持维生素D状态方面,维生素D2的效果不如维生素D3。
我们的目的是确定在维持血清25-羟基维生素D水平方面,维生素D2是否不如维生素D3有效,或者是否会增加25-羟基维生素D3的分解代谢。
这是一项针对18至84岁健康成年人的随机、安慰剂对照、双盲研究。这些成年人在冬季结束时,每天接受安慰剂、1000国际单位维生素D3、1000国际单位维生素D2或500国际单位维生素D2加500国际单位维生素D3,持续11周。
在研究开始时,60%的健康成年人维生素D缺乏。每天接受1000国际单位维生素D2(基线水平16.9±10.5纳克/毫升;11周后26.8±9.6纳克/毫升)、维生素D3(基线水平19.6±11.1纳克/毫升;11周后28.9±11.0纳克/毫升)或500国际单位维生素D2与500国际单位维生素D3组合(基线水平20.2±10.4纳克/毫升;11周后28.4±7.7纳克/毫升)的组中,25-羟基维生素D的循环水平升高幅度相同。每天接受1000国际单位维生素D2的组中,25-羟基维生素D3水平没有变化。1(此处原文可能有误,推测为1000)国际单位剂量的维生素D2或维生素D3未能使维生素D缺乏受试者的25-羟基维生素D水平升高至30纳克/毫升以上。
每天1000国际单位剂量的维生素D2在维持血清25-羟基维生素D水平方面与1000国际单位维生素D3同样有效,且对血清25-羟基维生素D3水平没有负面影响。因此,在维持25-羟基维生素D状态方面,维生素D2与维生素D3同样有效。