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维生素补充剂在慢性肾脏病中起作用吗?

Does Vitamin Supplementation Play a Role in Chronic Kidney Disease?

机构信息

1st Department of Urology, Medical University of Lodz, 90-549 Lodz, Poland.

出版信息

Nutrients. 2023 Jun 23;15(13):2847. doi: 10.3390/nu15132847.

DOI:10.3390/nu15132847
PMID:37447174
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10343669/
Abstract

Although the role of vitamins in the human body is proven, guidelines for patients with chronic kidney disease (CKD) remain unclear. This narrative review summarizes the findings of 98 studies of CKD and the effects of vitamin D, B, C, A, E, and K supplementation on patients on dialysis for CKD, with the aim of summarizing the existing guidelines. The findings are promising, showing the potential effectiveness of vitamin supplementation with, for example, vitamins B, D, or C. However, recommendations are still ambiguous, especially in the case of vitamins A and K, due to the potential toxicity associated with higher doses for patients. Continued research is needed to rigorously evaluate the effectiveness and carefully consider the potential risks of some vitamin supplementation for patients with CKD.

摘要

虽然维生素在人体中的作用已得到证实,但针对慢性肾脏病 (CKD) 患者的指南仍不明确。本综述总结了 98 项关于 CKD 患者的维生素 D、B、C、A、E 和 K 补充剂的研究结果,旨在总结现有的指南。研究结果很有前景,表明维生素补充剂(例如维生素 B、D 或 C)具有潜在的有效性。然而,由于高剂量可能导致毒性,因此建议仍然不够明确,尤其是对于维生素 A 和 K。需要进一步研究以严格评估某些维生素补充剂对 CKD 患者的有效性,并仔细考虑其潜在风险。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cba6/10343669/fcdde1b6b84e/nutrients-15-02847-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cba6/10343669/2c8bed00cd46/nutrients-15-02847-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cba6/10343669/fcdde1b6b84e/nutrients-15-02847-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cba6/10343669/2c8bed00cd46/nutrients-15-02847-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cba6/10343669/fcdde1b6b84e/nutrients-15-02847-g002.jpg

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Nutrients. 2023 Feb 8;15(4):860. doi: 10.3390/nu15040860.
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Effects of vitamin C supplementation on oxidative stress and serum paraoxonase/arylesterase activities in patients on long-term hemodialysis.长期血液透析患者补充维生素C对氧化应激及血清对氧磷酶/芳基酯酶活性的影响
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