Osim E E, Wyllie J H
Surgical Unit, Faculty of Clinical Sciences, University College London, Rayne Institute.
Acta Physiol Hung. 1991;78(2):173-9.
The role of the intestine as a source of platelet serotonin was investigated. Radioactive serotonin precursor. 5-Hydroxytryptophan was injected into enterectomised and sham-operated rats. Blood samples were taken at time intervals and serotonin uptake was estimated by radioactive counting. Soon (1-2 hrs) after surgery and under sodium pentobarbital anaesthesia, platelet 5HT activity was higher in enterectomised rats than in controls. The intestine may not be the major source of platelet serotonin.
研究了肠道作为血小板血清素来源的作用。将放射性血清素前体5-羟色氨酸注射到肠切除和假手术的大鼠体内。每隔一段时间采集血样，并通过放射性计数估算血清素摄取量。术后不久（1-2小时），在戊巴比妥钠麻醉下，肠切除大鼠的血小板5-羟色胺活性高于对照组。肠道可能不是血小板血清素的主要来源。
