Osim E E, Wyllie J H
Surgical Unit, Faculty of Clinical Sciences, University College London, United Kingdom.
Acta Physiol Hung. 1991;78(2):181-9.
Isolated rat lungs perfused with Krebs solution removed free radioactive 5-Hydroxytryptamine (5 HT or serotonin) from the fluid perfusing them. However, when platelets labelled with 111In-oxine to tag them individually, and with 14C-labelled 5 HT were also perfused via the lungs, there was no significant removal of the labelled 5 HT from the platelets. Paper chromatography showed that 46.7% of the platelet bound 5 HT was metabolished to an unidentified material. Rat lungs remove free 5 HT from plasma but not when it is platelet bound.
用 Krebs 溶液灌注的离体大鼠肺脏能从灌注液中去除游离的放射性 5-羟色胺（5-HT 或血清素）。然而，当用 111In-奥克辛标记以单独标记血小板，并将 14C 标记的 5-HT 也通过肺脏灌注时，标记的 5-HT 并未从血小板中显著去除。纸色谱法显示，与血小板结合的 5-HT 中有 46.7%代谢为一种未知物质。大鼠肺脏能从血浆中去除游离的 5-HT，但不能去除与血小板结合的 5-HT。
