Rioux Vincent, Legrand Philippe
Biochemistry and Human Nutrition Laboratory, Agrocampus Rennes, INRA USC 2012, Rennes, France.
Curr Opin Clin Nutr Metab Care. 2007 Nov;10(6):752-8. doi: 10.1097/MCO.0b013e3282f01a75.
This review summarizes recent findings on the biological functions of saturated fatty acids. Some of these findings suggest that saturated fatty acids may have important and specific regulatory roles in the cells. Until now these roles have largely been outweighed by the negative impact of dietary saturated fatty acids on atherosclerosis biomarkers. Elucidated biochemical mechanisms like protein acylation (N-myristoylation, S-palmitoylation) and putative physiological roles are described.
The review will focus on the following topics: new aspects on the metabolism of saturated fatty acids; recent reports on the biochemical functions of saturated fatty acids; current investigations on the physiological roles (elucidated and putative) of saturated fatty acids; and a discussion of the nutritional dietary recommendations (amounts and types) of saturated fatty acids.
Dietary saturated fatty acids are usually associated with negative consequences for human health. Experimental results on the relationship between doses, physiological effects, specificities and functions of individual saturated fatty acids are, however, conflicting. In this context, this review describes emerging recent evidence that some saturated fatty acids have important and specific biological roles. Such data are needed to allow a balanced view in terms of potential nutritional benefits of saturated fatty acids, and, if necessary, reassessment of the current nutritional dietary recommendations.
本综述总结了关于饱和脂肪酸生物学功能的近期研究发现。其中一些发现表明，饱和脂肪酸可能在细胞中具有重要且特定的调节作用。到目前为止，这些作用在很大程度上被膳食饱和脂肪酸对动脉粥样硬化生物标志物的负面影响所掩盖。文中描述了已阐明的生化机制，如蛋白质酰化（N-肉豆蔻酰化、S-棕榈酰化）以及假定的生理作用。
本综述将聚焦于以下主题：饱和脂肪酸代谢的新方面；关于饱和脂肪酸生化功能的近期报道；当前对饱和脂肪酸生理作用（已阐明的和假定的）的研究；以及对饱和脂肪酸营养膳食建议（数量和类型）的讨论。
膳食饱和脂肪酸通常与对人类健康的负面影响相关。然而，关于个体饱和脂肪酸的剂量、生理效应、特异性和功能之间关系的实验结果相互矛盾。在此背景下，本综述描述了近期出现的一些证据，表明某些饱和脂肪酸具有重要且特定的生物学作用。需要此类数据以便在饱和脂肪酸潜在的营养益处方面形成平衡的观点，并在必要时重新评估当前的营养膳食建议。
