Mitzner Steffen R
Division of Nephrology, Department of Medicine, University of Rostock, Rostock, Germany.
Curr Opin Nephrol Hypertens. 2007 Nov;16(6):589-95. doi: 10.1097/MNH.0b013e3282f0abdb.
To review the current literature about albumin dialysis-based liver support.
The literature suggests that the molecular adsorbent recirculating system of albumin dialysis is a useful tool to treat acute liver failure, decompensated chronic liver disease, and to provide a bridge for patients to liver transplantation. The reported clinical benefits include an improvement in central and local haemodynamics as well as organ functions (liver, brain, kidney). The treatment can contribute to liver regeneration and prolongation of patient survival. Proper patient selection is critical for clinical success.
Albumin regeneration has developed into a central component of modern liver support technologies. Albumin dialysis using the molecular adsorbent recirculating system is the most frequently used and best studied liver support technique at present time. Ongoing and future clinical studies will help define the place of albumin dialysis in liver failure therapy.
回顾目前有关基于白蛋白透析的肝脏支持的文献。
文献表明，白蛋白透析的分子吸附循环系统是治疗急性肝衰竭、失代偿性慢性肝病以及为患者提供肝移植桥梁的有用工具。报道的临床益处包括改善中心和局部血流动力学以及器官功能（肝脏、大脑、肾脏）。该治疗有助于肝脏再生并延长患者生存期。正确选择患者对临床成功至关重要。
白蛋白再生已发展成为现代肝脏支持技术的核心组成部分。使用分子吸附循环系统的白蛋白透析是目前最常用且研究最充分的肝脏支持技术。正在进行的和未来的临床研究将有助于确定白蛋白透析在肝衰竭治疗中的地位。
