Kjøller Kim, Friis Søren, Lipworth Loren, McLaughlin Joseph K, Olsen Jørgen H
Copenhagen, Denmark; and Rockville, Md. From the Institute of Cancer Epidemiology, Danish Cancer Society; the International Epidemiology Institute; and Sanofi Pasteur MSD.
Plast Reconstr Surg. 2007 Dec;120(7 Suppl 1):129S-134S. doi: 10.1097/01.prs.0000286571.93392.00.
To assess whether maternal cosmetic breast implants are associated with adverse health outcomes among offspring, the authors examined published findings of epidemiologic studies that addressed this hypothesis.
Four epidemiologic studies, all from Scandinavia, were identified. Women with breast implants were identified from existing public and private registers of patients, and their offspring were traced through nationwide population and birth registers. The studies included a total of 11,445 women with breast implants and 3248 children born after the mothers' implantation procedures. Comparison was made with children born to mothers who had undergone other cosmetic surgery or general population controls. Outcomes under study were congenital malformations, hospitalization for esophageal and rheumatic disorders, and perinatal mortality.
Overall, the studied outcomes were similar between children born to mothers with breast implants and children of controls, and between children born before and after maternal breast implantation. In the Danish studies, significantly elevated rates of esophageal disorders were observed for children born before (observed-to-expected ratio, 2.0; 95 percent confidence interval, 1.3 to 2.8) but not after (observed-to-expected ratio, 1.3; 95 percent confidence interval, 0.5 to 2.9) the mother's breast implant surgery. Similar excesses were observed among control children born before and after maternal breast reduction. In the Swedish and Finnish studies, all risk estimates for malformations and perinatal health were close to unity.
Rates of esophageal and rheumatic disorders, congenital malformations, and perinatal mortality and hospitalization were comparable between children born to mothers with breast implants and children born to mothers who had undergone other cosmetic surgery.
为评估母亲的隆胸植入物是否与后代的不良健康结局相关，作者审查了针对这一假设的流行病学研究的已发表结果。
确定了四项均来自斯堪的纳维亚半岛的流行病学研究。通过现有的公共和私人患者登记册确定隆胸女性，并通过全国人口和出生登记册追踪其后代。这些研究总共纳入了11445名隆胸女性以及3248名在母亲隆胸手术后出生的儿童。将其与接受过其他整形手术的母亲所生子女或一般人群对照进行比较。所研究的结局包括先天性畸形、因食管疾病和风湿性疾病住院以及围产期死亡率。
总体而言，隆胸母亲所生子女与对照组子女之间，以及母亲隆胸前后出生的子女之间，所研究的结局相似。在丹麦的研究中，母亲隆胸手术前出生的儿童食管疾病发生率显著升高（观察值与预期值之比为2.0；95%置信区间为1.3至2.8），但隆胸手术后出生的儿童则未出现这种情况（观察值与预期值之比为1.3；95%置信区间为0.5至2.9）。在母亲缩胸手术前后出生的对照儿童中也观察到了类似的超额情况。在瑞典和芬兰的研究中，所有关于畸形和围产期健康的风险估计值均接近1。
隆胸母亲所生子女与接受过其他整形手术的母亲所生子女在食管疾病、风湿性疾病、先天性畸形、围产期死亡率和住院率方面相当。
