Zhang Jianjun, Dhakal Ishwori, Ning Baitang, Kesteloot Hugo
Department of Epidemiology, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA.
Eur J Cancer Prev. 2008 Feb;17(1):18-27. doi: 10.1097/CEJ.0b013e32809b4ccd.
Little is known about trends in pancreatic cancer mortality in individual states of the US and its whole population. This study aimed to describe the patterns and trends of pancreatic cancer mortality in Arkansas, 1969-2002, using the US national rates as a reference. Joinpoint regression analyses were performed to evaluate trends in age-standardized mortality rates of pancreatic cancer by age group, sex, and race, using data obtained from the National Center for Health Statistics. Throughout the period examined, mortality decreased in young and middle-aged people (<60 years) and men but increased in old people (>/=60 years) and women. A continuous fall in mortality occurred among whites except for a transient rise in the late 1970s. For blacks, mortality rates did not cease to increase until 1995. Unlike in Arkansas, a monotonic upward or downward trend in mortality by age group and sex was not observed in the US. A decline of mortality stopped in 1997 for US whites. Recent decreasing trends were more pronounced in Arkansas blacks than in US blacks. Changes of pancreatic cancer mortality in the last three decades in Arkansas remarkably differed by age, sex, and race and were different in patterns from those of the US population.
关于美国各州以及全体人口的胰腺癌死亡率趋势，人们了解甚少。本研究旨在以美国全国死亡率为参照，描述1969年至2002年阿肯色州胰腺癌死亡率的模式和趋势。利用从美国国家卫生统计中心获取的数据，进行连接点回归分析，以评估按年龄组、性别和种族划分的胰腺癌年龄标准化死亡率趋势。在整个研究期间，年轻和中年人群（<60岁）以及男性的死亡率下降，而老年人群（≥60岁）和女性的死亡率上升。除了20世纪70年代末有短暂上升外，白人的死亡率持续下降。对于黑人，死亡率直到1995年才停止上升。与阿肯色州不同，在美国未观察到按年龄组和性别划分的死亡率呈单调上升或下降趋势。美国白人的死亡率下降在1997年停止。最近阿肯色州黑人的下降趋势比美国黑人更明显。过去三十年阿肯色州胰腺癌死亡率的变化在年龄、性别和种族方面显著不同，且模式与美国总体人群不同。
