Aviner Shraga, Dabby Dan, London Daniel, Feinmesser Meora, Ash Shifra, Steinberg Ran, Jakim Itzhak
Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Isreal.
J Pediatr Hematol Oncol. 2007 Dec;29(12):848-50. doi: 10.1097/MPH.0b013e3181581587.
An Ethiopian girl 14 years and 11 months of age presented with bilateral transcervical hip fractures. Workup revealed severe vitamins D and C deficiencies with secondary hyperparathyroidism. Imaging studies showed bilateral radiolucent metaphyseal bands with multiple lytic lesions in long bones. A mass in the right flank was found to be renal cell carcinoma (RCC). Currently, 9 months postsurgery and supplemental therapy, the patient is fully ambulatory and free of pain. This first report of asymptomatic RCC in severely vitamin D deficient child highlights the relation of RCC to vitamin D deficiency and emphasizes the importance of careful evaluation of these children.
一名14岁11个月大的埃塞俄比亚女孩出现双侧经颈髋关节骨折。检查发现严重的维生素D和C缺乏伴继发性甲状旁腺功能亢进。影像学研究显示双侧干骺端透亮带,长骨有多个溶骨性病变。右侧腹部的肿块被发现是肾细胞癌(RCC)。目前,术后9个月并接受补充治疗,患者可完全行走且无疼痛。这例严重维生素D缺乏儿童无症状肾细胞癌的首例报告突出了肾细胞癌与维生素D缺乏的关系,并强调了对这些儿童进行仔细评估的重要性。