Arngrímsson Sigurbjörn A, Sveinsson Torarinn, Gunnarsdóttir Ingibjörg, Pálsson Gestur I, Jóhannsson Erlingur, Thorsdottir Inga
Center for Sport and Health Sciences, Iceland University of Education, Laugarvatn, Iceland.
Med Sci Sports Exerc. 2008 Jan;40(1):43-9. doi: 10.1249/mss.0b013e31815988d7.
To explore the relationship between varying aerobic fitness (fitness), fatness, and fasting insulin levels in healthy children.
A population-based sample of 9-yr-old (9YO, 47 boys, 56 girls) and 15-yr-old (15YO, 53 boys, 51 girls) Icelandic children. Body fatness was evaluated via body mass index, waist circumference adjusted for height (waist adj), and sum of four skinfolds. Fitness was assessed with a graded maximal cycle ergometer test. Fasting insulin was measured using an ECLIA.
Fasting insulin correlated to all fatness measures (9YO, r = 0.43-0.46, P < 0.001; 15YO, r = 0.30-0.37, P < 0.003) and fitness (9YO, r = -0.29, P = 0.003; 15YO, r = -0.32, P = 0.001). Adjustment for fitness did not affect the relations between fatness and fasting insulin in 9YO (r = 0.33-0.37, P < 0.001); however, only waist adj remained significantly related to fasting insulin (r = 0.24, P = 0.016) in 15YO. Children in the upper half of fitness and fatness split on the median did not differ in fasting insulin from children in the upper half of fitness but lower half of fatness. Fatness was related to fasting insulin in 9YO (r = 0.51-0.54, P = 0.001) and 15YO (r = 0.31-0.35, P = 0.011-0.028) in the lower half of fitness, but no association was observed in the upper half of fitness in either group.
Fatness has a greater association with fasting insulin than fitness, especially among 9YO; however, fitness attenuates the adverse relation of fatness to fasting insulin in 15YO but does not change it in 9YO. In both age groups, being fitter and fatter does not result in greater fasting insulin than being fitter and leaner, and fatness is primarily associated with fasting insulin in lower-fit children.
探讨健康儿童不同有氧适能（体能）、肥胖程度与空腹胰岛素水平之间的关系。
以冰岛9岁（9YO，47名男孩，56名女孩）和15岁（15YO，53名男孩，51名女孩）儿童为基于人群的样本。通过体重指数、根据身高调整的腰围（调整后腰围）和四处皮褶厚度之和评估身体肥胖程度。通过递增式最大运动负荷蹬车试验评估体能。使用电化学发光免疫分析法测量空腹胰岛素。
空腹胰岛素与所有肥胖程度指标相关（9岁组，r = 0.43 - 0.46，P < 0.001；15岁组，r = 0.30 - 0.37，P < 0.003）以及与体能相关（9岁组，r = -0.29，P = 0.003；15岁组，r = -0.32，P = 0.001）。对体能进行校正后，9岁组肥胖程度与空腹胰岛素之间的关系未受影响（r = 0.33 - 0.37，P < 0.001）；然而，在15岁组中，仅调整后腰围与空腹胰岛素仍显著相关（r = 0.24，P = 0.016）。体能和肥胖程度处于中位数以上和以下分组的儿童，其空腹胰岛素水平与体能处于中位数以上但肥胖程度处于中位数以下分组的儿童并无差异。在体能处于下半部分的9岁组（r = 0.51 - 0.54，P = 0.001）和15岁组（r = 0.31 - 0.35，P = 0.011 - 0.028）中，肥胖程度与空腹胰岛素相关，但在两组体能处于上半部分的儿童中未观察到相关性。
肥胖程度与空腹胰岛素的关联比体能更大，尤其是在9岁儿童中；然而，体能减弱了15岁儿童中肥胖程度与空腹胰岛素之间的不良关系，但在9岁儿童中未改变这种关系。在两个年龄组中，体能较好且较胖的儿童空腹胰岛素水平并不高于体能较好且较瘦的儿童，并且肥胖程度主要与体能较差儿童的空腹胰岛素相关。
