Smyth Shawn F, Beversdorf David Q
Department of Neurology, The Ohio State University, Columbus, OH 43210, USA.
Cogn Behav Neurol. 2007 Dec;20(4):225-9. doi: 10.1097/WNN.0b013e31815e6244.
To evaluate performance on a cognitive flexibility task after administration of a dopaminergic agonist.
L-3,4-dihydroxyphenylalanine, which is converted into dopamine and norepinephrine, results in a restriction of the semantic network in priming experiments. Recent evidence suggests that flexibility of access to semantic networks in problem solving is mediated by the noradrenergic system. We wished to determine if dopaminergic agonists also affect this type of cognitive flexibility.
Eighty-four subjects were tested twice on an anagram task, once 1 hour after bromocriptine (dopamine agonist) and once 1 hour after placebo administration.
No difference was detected between placebo and bromocriptine on anagram performance.
Therefore, modulation of this type of cognitive flexibility does not seem to be mediated by the dopaminergic system. This suggests that the noradrenergic modulation of cognitive flexibility previously reported does not seem to extend to the dopaminergic system among catecholamines.
评估给予多巴胺能激动剂后在认知灵活性任务上的表现。
L-3,4-二羟基苯丙氨酸可转化为多巴胺和去甲肾上腺素，在启动实验中会导致语义网络受限。近期证据表明，解决问题时语义网络的访问灵活性由去甲肾上腺素能系统介导。我们希望确定多巴胺能激动剂是否也会影响这种认知灵活性。
84名受试者在字谜任务上接受两次测试，一次在服用溴隐亭（多巴胺激动剂）1小时后，一次在服用安慰剂1小时后。
在字谜表现上，未检测到安慰剂和溴隐亭之间存在差异。
因此，这种认知灵活性的调节似乎不由多巴胺能系统介导。这表明先前报道的去甲肾上腺素能对认知灵活性的调节似乎并不扩展到儿茶酚胺中的多巴胺能系统。
