Xu Zhe, Ding Zuoding, Xu Xu, Xie Xiaoan
Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China.
Chirality. 2008 Feb;20(2):147-50. doi: 10.1002/chir.20513.
The HPLC chiral separation of 21 kinds of 2-aryl-1,3-dicarbonyl analogues was investigated in normal phase mode with amylose tris(3,5-dimethylphenylcarbamate), amylose tris((S)-1-phenylethylcarbamate), cellulose tris(3,5-dimethylphenylcarbamate), and cellulose tris(4-methylbenzoate) chiral stationary phases, respectively. The whole set of 2-aryl-1,3-dicarbonyl analogues shows better enantioselectivity and enantioseparation on amylose tris(3,5-dimethylphenyl carbamate) (Chiralpak AD-H). The temperature dependence of enantioselectivity was studied to improve the enantioseparation. In addition, efforts are made to relate analyte structure with the quality of the achieved chiral separation.
分别采用直链淀粉三（3,5-二甲基苯基氨基甲酸酯）、直链淀粉三（（S）-1-苯基乙基氨基甲酸酯）、纤维素三（3,5-二甲基苯基氨基甲酸酯）和纤维素三（4-甲基苯甲酸酯）手性固定相，在正相模式下研究了21种2-芳基-1,3-二羰基类似物的高效液相色谱手性分离。整套2-芳基-1,3-二羰基类似物在直链淀粉三（3,5-二甲基苯基氨基甲酸酯）（Chiralpak AD-H）上表现出更好的对映体选择性和对映体分离效果。研究了对映体选择性的温度依赖性以改善对映体分离。此外，还努力将分析物结构与所实现的手性分离质量联系起来。
