Thind Amandeep S, Leung General, Munce Nigel R, Graham John J, Anderson Kevan J T, Dick Alexander J, Strauss Bradley H, Wright Graham A, Foster F Stuart
Department of Medical Biophysics, Sunnybrook Health Sciences Centre, University of Toronto, 2075 Bayview Ave, S6 39, Toronto, Ontario M4N 3M5, Canada.
Ultrason Imaging. 2007 Jul;29(3):167-81. doi: 10.1177/016173460702900303.
The aim of the current study is to investigate the ability of micro-ultrasound (microUS) to identify microvasculature in CTOs in vivo. Results are compared with MRI studies. CTOs were developed in nine porcine superficial femoral arteries (SFA) by percutaneous insertion of a dissolvable polymer plug. This model is characterized by acute thrombosis that later organizes into a fibrotic CTO containing abundant microchannels. 3D microUS images with Power Doppler (PD) overlays from the arteries were acquired at two timepoints: one and eight weeks after placement ofthe polymerplug. Phase contrast MRI and contrast enhanced MRI was also performed. Imaging was performed transcutaneously. Microvessels were identified in vivo in six of eight CTOs using microUS, and in three of seven CTO vessels with MRI, compared with five of seven seen histologically. PW Doppler profiles showed pulsatile blood velocities of approximately 2 cm/s. Intraluminal microvessels within CTOs can be consistently identified by 3D microUS. This technique appears to be more sensitive than MRI. MicroUS may play a role in guiding CTO interventions.
本研究的目的是调查微超声（microUS）在体内识别慢性完全闭塞病变（CTO）中微血管的能力。将结果与MRI研究进行比较。通过经皮插入可溶解的聚合物栓塞，在九条猪股浅动脉（SFA）中形成CTO。该模型的特征是急性血栓形成，随后演变成含有丰富微通道的纤维化CTO。在两个时间点采集动脉的带有功率多普勒（PD）叠加的三维微超声图像：放置聚合物栓塞后1周和8周。还进行了相位对比MRI和对比增强MRI。经皮进行成像。使用微超声在八个CTO中的六个中在体内识别出微血管，使用MRI在七个CTO血管中的三个中识别出微血管，相比之下，组织学上可见七个中的五个。脉冲波多普勒频谱显示脉动血流速度约为2cm/s。通过三维微超声可以一致地识别CTO内的腔内微血管。该技术似乎比MRI更敏感。微超声可能在指导CTO干预中发挥作用。
