Heinold A, Opelz G, Scherer S, Ruhenstroth A, Laux G, Doehler B, Tran T H
Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany.
Am J Transplant. 2008 Jan;8(1):95-102. doi: 10.1111/j.1600-6143.2007.02042.x. Epub 2007 Dec 18.
In hematopoietic stem cell transplantation (HSCT), disparities between recipients and donors for minor histocompatibility antigens (mHags) have been shown to be related to graft-versus-host disease (GVHD) and graft-versus-leukemia (GVL) effects. We investigated the effect of mHag mismatches on kidney allograft survival. Out of 33 785 kidney transplants on which DNA and clinical data were available to the Collaborative Transplant Study (CTS), 702 recipient/donor pairs could be identified as HLA-A, -B and -DRB1 matched first transplants of Caucasian origin. These pairs were typed for genetic polymorphisms of the mHags HA-1, HA-2, HA-3, HA-8, HB-1, ACC-1 and UGT2B17. Because mHags are presented in an HLA-restricted manner, only HLA-A02 positive pairs were included in the analysis of HA-1, HA-2 and HA-8. Similarly, only HLA-A01, HLA-B44 and HLA-A24 positive pairs were considered for the evaluation of HA-3, HB-1 and ACC-1, respectively, whereas UGT2B17 compatible transplants were assessed in HLA-A29 and HLA-B44 positive pairs. None of the mHag disparities showed a statistically significant effect on death-censored 5-year graft survival. This report represents the first large-scale study on the relevance of mHags in kidney transplantation.
在造血干细胞移植（HSCT）中，已表明受者与供者之间次要组织相容性抗原（mHags）的差异与移植物抗宿主病（GVHD）和移植物抗白血病（GVL）效应相关。我们研究了mHag错配对肾移植存活的影响。在协作移植研究（CTS）可获取DNA和临床数据的33785例肾移植中，702对受者/供者可被鉴定为白种人来源的HLA - A、- B和 - DRB1匹配的首次移植。对这些配对进行了mHags HA - 1、HA - 2、HA - 3、HA - 8、HB - 1、ACC - 1和UGT2B17的基因多态性分型。由于mHags以HLA限制的方式呈递，仅HLA - A02阳性配对被纳入HA - 1、HA - 2和HA - 8的分析。同样，仅分别将HLA - A01、HLA - B44和HLA - A24阳性配对用于HA - 3、HB - 1和ACC - 1的评估，而UGT2B17相容性移植在HLA - A29和HLA - B44阳性配对中进行评估。没有mHag差异对死亡删失的5年移植存活显示出统计学上的显著影响。本报告是关于mHags在肾移植中相关性的第一项大规模研究。
