Department of Pathology, University of Maryland School of Medicine, 22 South Greene Street, Baltimore, MD, USA.
Diagn Pathol. 2007 Dec 19;2:49. doi: 10.1186/1746-1596-2-49.
Post-transplant lymphoproliferative disorder (PTLD) is a spectrum of hematological diseases arising in context of immunosuppression after organ transplantation. PTLD can involve any organ; however, it is extremely rare in oral cavity.
Using morphologic and immunophenotypic approaches we have studied a case of monomorphic PTLD of the tongue that developed in a patient following unilateral kidney and pancreas transplantation on immunosuppressive therapy. Additionally, cases of PTLD in the oral cavity were reviewed in the English literature.
The neoplasm showed large cell morphology and B-cell phenotype. In situ hybridization for Epstein-Barr virus was positive. Complete remission was obtained after decreasing immunosuppressive therapy. The patient remained in remission at 790 days' follow up.
This rare case increased our awareness of PTLD in the oral cavity of patients following solid organ transplantation and immunosuppressive therapy.
移植后淋巴组织增生性疾病（PTLD）是一组发生于器官移植后免疫抑制背景下的血液系统疾病。PTLD 可累及任何器官；然而，其在口腔中极为罕见。
我们采用形态学和免疫表型方法研究了一例发生于单侧肾和胰腺移植后免疫抑制治疗患者舌部的单形性 PTLD。此外，我们还复习了英文文献中口腔 PTLD 的病例。
肿瘤呈现大细胞形态和 B 细胞表型。原位杂交检测 Epstein-Barr 病毒阳性。减少免疫抑制治疗后获得完全缓解。患者在 790 天的随访中仍处于缓解状态。
该罕见病例提高了我们对实体器官移植和免疫抑制治疗患者口腔 PTLD 的认识。
