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The phox domain of sorting nexin 5 lacks phosphatidylinositol 3-phosphate (PtdIns(3)P) specificity and preferentially binds to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2).分选连接蛋白5的PX结构域缺乏磷脂酰肌醇3-磷酸(PtdIns(3)P)特异性,且优先结合磷脂酰肌醇4,5-二磷酸(PtdIns(4,5)P2)。
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本文引用的文献

1
Association between genetic variants in SORL1 and autopsy-confirmed Alzheimer disease.SORL1基因变异与尸检确诊的阿尔茨海默病之间的关联。
Neurology. 2008 Mar 11;70(11):887-9. doi: 10.1212/01.wnl.0000280581.39755.89. Epub 2007 Oct 31.
2
Sorl1 as an Alzheimer's disease predisposition gene?Sorl1是一种阿尔茨海默病易感基因?
Neurodegener Dis. 2008;5(2):60-4. doi: 10.1159/000110789. Epub 2007 Nov 1.
3
SORL1 variants and risk of late-onset Alzheimer's disease.SORL1基因变异与晚发型阿尔茨海默病风险
Neurobiol Dis. 2008 Feb;29(2):293-6. doi: 10.1016/j.nbd.2007.09.001. Epub 2007 Sep 16.
4
Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study.基于磁共振成像(MRI)和认知测试指标的脑老化遗传关联:弗雷明汉心脏研究中的全基因组关联和连锁分析
BMC Med Genet. 2007 Sep 19;8 Suppl 1(Suppl 1):S15. doi: 10.1186/1471-2350-8-S1-S15.
5
SorLA/LR11 regulates processing of amyloid precursor protein via interaction with adaptors GGA and PACS-1.SorLA/LR11通过与衔接蛋白GGA和PACS-1相互作用来调节淀粉样前体蛋白的加工过程。
J Biol Chem. 2007 Nov 9;282(45):32956-64. doi: 10.1074/jbc.M705073200. Epub 2007 Sep 12.
6
Neuronal LR11/sorLA expression is reduced in mild cognitive impairment.在轻度认知障碍中,神经元LR11/sorLA的表达降低。
Ann Neurol. 2007 Dec;62(6):640-7. doi: 10.1002/ana.21190.
7
The association between genetic variants in SORL1 and Alzheimer disease in an urban, multiethnic, community-based cohort.在一个基于城市、多民族社区的队列中,SORL1基因变异与阿尔茨海默病之间的关联。
Arch Neurol. 2007 Apr;64(4):501-6. doi: 10.1001/archneur.64.4.501.
8
The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease.神经元sortilin相关受体SORL1与阿尔茨海默病存在基因关联。
Nat Genet. 2007 Feb;39(2):168-77. doi: 10.1038/ng1943. Epub 2007 Jan 14.
9
N-linked oligosaccharides on the low density lipoprotein receptor homolog SorLA/LR11 are modified with terminal GalNAc-4-SO4 in kidney and brain.低密度脂蛋白受体同源物SorLA/LR11上的N-连接寡糖在肾脏和大脑中被末端N-乙酰半乳糖胺-4-硫酸修饰。
J Biol Chem. 2007 Jan 19;282(3):1873-81. doi: 10.1074/jbc.M606455200. Epub 2006 Nov 22.
10
Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein.神经元分选蛋白相关受体sorLA/LR11调节淀粉样前体蛋白的加工过程。
Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13461-6. doi: 10.1073/pnas.0503689102. Epub 2005 Sep 7.

Alzheimer's disease: advances in trafficking.

作者信息

Mayeux Richard, Hyslop Peter St George

机构信息

Taub Institute on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.

出版信息

Lancet Neurol. 2008 Jan;7(1):2-3. doi: 10.1016/S1474-4422(07)70298-3.

DOI:10.1016/S1474-4422(07)70298-3
PMID:18093545
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2739745/
Abstract
摘要