Aoki Kazuko, Cortés Alma Rosa, Ramírez María Del Carmen, Gómez-Hernández Martín, López-Muñoz Francisco J
Departamento Sistemas Biológicos, Universidad Autónoma Metropolitana-Xochimilco, Calzada del Hueso 1100, Colonia Villa Quietud, C.P. 04960, México, D.F., Mexico.
J Ethnopharmacol. 2008 Feb 28;116(1):96-101. doi: 10.1016/j.jep.2007.11.004. Epub 2007 Nov 17.
Mirabilis jalapa Linn is a well-studied plant. The indigenous people of Mexico use Mirabilis jalapa to cure many infirmities including dysentery, diarrhea, muscular pain and abdominal colic. In the present investigation, we have further characterized some pharmacological properties of an extract of Mirabilis jalapa flowers; therefore, we intend to contribute to understand the pharmacological effects and clarify the complex use of this medicinal plant.
The extract of Mirabilis jalapa (1-1000 mug/mL) exhibits an inhibitory effect (IC(50)=18+/-0.7 micorg/mL) on gut smooth muscle contractility whereas it stimulates the contraction of rabbit aortic muscle (EC(50)=11.60+/-0.26 micorg/mL) in a concentration-dependent manner.
These effects were not due to either ACh or HIS receptors blockage, IP(3), cAMP, cGMP, Ca(2+) release from intracellular storage, or protein kinase mediated contraction-relaxation mechanisms. The effects inducted by the Mirabilis jalapa extract may involve a serotoninergic mechanism, which, in turn, interacts with other adrenergic systems. Further studies are necessary to identify the active compounds within the extract and to elucidate the mechanism of action.
紫茉莉是一种经过充分研究的植物。墨西哥的原住民使用紫茉莉来治疗多种疾病，包括痢疾、腹泻、肌肉疼痛和腹部绞痛。在本研究中，我们进一步对紫茉莉花朵提取物的一些药理特性进行了表征；因此，我们旨在有助于理解其药理作用并阐明这种药用植物的复杂用途。
紫茉莉提取物（1 - 1000微克/毫升）对肠道平滑肌收缩具有抑制作用（IC50 = 18 ± 0.7微克/毫升），而它以浓度依赖性方式刺激兔主动脉肌肉收缩（EC50 = 11.60 ± 0.26微克/毫升）。
这些作用并非由于乙酰胆碱或组胺受体阻断、肌醇三磷酸（IP3）、环磷酸腺苷（cAMP）、环磷酸鸟苷（cGMP）、细胞内储存的钙离子释放或蛋白激酶介导的收缩 - 舒张机制。紫茉莉提取物诱导的作用可能涉及5 - 羟色胺能机制，进而与其他肾上腺素能系统相互作用。需要进一步研究以确定提取物中的活性化合物并阐明其作用机制。
