Launching a ubiquitination cascade at DNA breaks.
作者信息
Yang Xiaohong H, Zou Lee
机构信息
Massachusetts General Hospital Cancer Center and Department of Pathology, Harvard Medical School, Charlestown, MA 02129, USA.
出版信息
Proc Natl Acad Sci U S A. 2007 Dec 26;104(52):20645-6. doi: 10.1073/pnas.0710916105. Epub 2007 Dec 19.
Abstract
摘要
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Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase.RNF8泛素连接酶对DNA损伤反应的调控。
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RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly.RNF8通过组蛋白泛素化和检查点蛋白组装来转导DNA损伤信号。
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RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins.RNF8在DNA双链断裂处使组蛋白泛素化，并促进修复蛋白的组装。
Cell. 2007 Nov 30;131(5):887-900. doi: 10.1016/j.cell.2007.09.040. Epub 2007 Nov 20.
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