Schelstraete P, Van Daele S, De Boeck K, Proesmans M, Lebecque P, Leclercq-Foucart J, Malfroot A, Vaneechoutte M, De Baets F
Cystic Fibrosis Centres, Ghent University Hospital, Ghent, Belgium.
Eur Respir J. 2008 Apr;31(4):822-9. doi: 10.1183/09031936.00088907. Epub 2007 Dec 19.
The source of acquisition of Pseudomonas aeruginosa in cystic fibrosis (CF) patients remains unknown. Patient-to-patient transmission has been well documented but the role of the environment as a source of initial infection is as yet unclear. In the present study, the origin of the first P. aeruginosa isolate in CF patients was investigated by comparing the P. aeruginosa genotype(s) from newly infected patients with genotypes of P. aeruginosa isolates from the home environment and from other patients from the same CF centre. A total of 50 newly infected patients were studied. P. aeruginosa could be cultured from 5.9% of the environmental samples, corresponding to 18 patients. For nine of these, the genotype of the environmental P. aeruginosa isolate was identical to the patient's isolate. In total, 72% of the environmental P. aeruginosa isolates were encountered in the bathroom. Patient-to-patient transmission within the CF centre could not be ruled out for three patients. In summary, a low prevalence of Pseudomonas aeruginosa was found in the home environment of the newly infected cystic fibrosis patients. The bathroom should be targeted in any preventive cleaning procedures. An environmental source of the new infection could not be ruled out in nine patients.
囊性纤维化（CF）患者中铜绿假单胞菌的感染源仍不清楚。患者之间的传播已有充分记录，但环境作为初始感染源的作用尚不清楚。在本研究中，通过比较新感染患者的铜绿假单胞菌基因型与来自家庭环境以及同一CF中心其他患者的铜绿假单胞菌分离株的基因型，对CF患者中首次分离出的铜绿假单胞菌的来源进行了调查。共研究了50名新感染患者。5.9%的环境样本中可培养出铜绿假单胞菌，对应18名患者。其中9名患者的环境铜绿假单胞菌分离株基因型与患者分离株相同。总共72%的环境铜绿假单胞菌分离株出现在浴室中。CF中心内3名患者不能排除患者之间的传播。总之，在新感染的囊性纤维化患者家庭环境中发现铜绿假单胞菌的患病率较低。在任何预防性清洁程序中都应以浴室为目标。9名患者不能排除新感染的环境来源。
