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Comments on "Ethanol sensitivity of GABAergic currents in cerebellar granule neurons is not increased by a single amino acid change (R100Q) in the alpha6 GABA(A) receptor subunit".

作者信息

Otis Thomas S

出版信息

J Pharmacol Exp Ther. 2008 Jan;324(1):399-400; author reply 401-3. doi: 10.1124/jpet.107.131557.

DOI:10.1124/jpet.107.131557
PMID:18094322
Abstract
摘要

相似文献

1
Comments on "Ethanol sensitivity of GABAergic currents in cerebellar granule neurons is not increased by a single amino acid change (R100Q) in the alpha6 GABA(A) receptor subunit".
J Pharmacol Exp Ther. 2008 Jan;324(1):399-400; author reply 401-3. doi: 10.1124/jpet.107.131557.
2
Ethanol sensitivity of GABAergic currents in cerebellar granule neurons is not increased by a single amino acid change (R100Q) in the alpha6 GABAA receptor subunit.小脑颗粒神经元中GABA能电流的乙醇敏感性不会因α6 GABAA受体亚基中的单个氨基酸变化（R100Q）而增加。
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Modulation of GABAA receptors in cerebellar granule neurons by ethanol: a review of genetic and electrophysiological studies.乙醇对小脑颗粒神经元中GABAA受体的调节作用：遗传学和电生理学研究综述
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Sensitivity of GABAergic Tonic Currents to Acute Ethanol in Cerebellar Granule Neurons is Not Age- or δ Subunit-Dependent in Developing Rats.在发育中的大鼠中，小脑颗粒神经元中GABA能紧张性电流对急性乙醇的敏感性不依赖于年龄或δ亚基。
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Effects of ethanol on tonic GABA currents in cerebellar granule cells and mammalian cells recombinantly expressing GABA(A) receptors.乙醇对小脑颗粒细胞及重组表达GABA(A)受体的哺乳动物细胞中强直GABA电流的影响。
J Pharmacol Exp Ther. 2006 Oct;319(1):431-8. doi: 10.1124/jpet.106.106260. Epub 2006 Jul 14.
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Alcohol enhances GABAergic transmission to cerebellar granule cells via an increase in Golgi cell excitability.酒精通过增加高尔基细胞的兴奋性来增强向小脑颗粒细胞的γ-氨基丁酸能传递。
J Neurosci. 2004 Apr 14;24(15):3746-51. doi: 10.1523/JNEUROSCI.0067-04.2004.
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Alcohol-induced motor impairment caused by increased extrasynaptic GABA(A) receptor activity.突触外GABA(A)受体活性增加导致酒精诱导的运动障碍。
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The cerebellar GABAAR α6-R100Q polymorphism alters ligand binding in outbred Sprague-Dawley rats in a similar manner as in selectively bred AT and ANT rats.小脑 GABAAR α6-R100Q 多态性以类似于选择性繁殖的 AT 和 ANT 大鼠的方式改变了杂交 Sprague-Dawley 大鼠的配体结合。
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Differential effects of methylmercury on gamma-aminobutyric acid type A receptor currents in rat cerebellar granule and cerebral cortical neurons in culture.甲基汞对培养的大鼠小脑颗粒神经元和大脑皮质神经元中γ-氨基丁酸A型受体电流的不同影响。
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Repeated intermittent alcohol exposure during the third trimester-equivalent increases expression of the GABA(A) receptor δ subunit in cerebellar granule neurons and delays motor development in rats.在相当于妊娠晚期的阶段反复间歇性酒精暴露会增加大鼠小脑颗粒神经元中γ-氨基丁酸A（GABA(A)）受体δ亚基的表达，并延迟其运动发育。
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引用本文的文献

1
A reinforcing circuit action of extrasynaptic GABAA receptor modulators on cerebellar granule cell inhibition.突触外GABAA受体调节剂对小脑颗粒细胞抑制的增强回路作用。
PLoS One. 2013 Aug 19;8(8):e72976. doi: 10.1371/journal.pone.0072976. eCollection 2013.
2
A major QTL for acute ethanol sensitivity in the alcohol tolerant and non-tolerant selected rat lines.酒精耐受和不耐受选择大鼠品系急性乙醇敏感性的一个主要 QTL。
Genes Brain Behav. 2009 Aug;8(6):611-25. doi: 10.1111/j.1601-183X.2009.00496.x. Epub 2009 Mar 23.
3
Physiology and pharmacology of alcohol: the imidazobenzodiazepine alcohol antagonist site on subtypes of GABAA receptors as an opportunity for drug development?
酒精的生理学与药理学：GABAA受体亚型上的咪唑并苯二氮䓬类酒精拮抗剂位点——药物研发的契机？
Br J Pharmacol. 2008 May;154(2):288-98. doi: 10.1038/bjp.2008.32. Epub 2008 Feb 18.