伊朗东南部两个民族的人类白细胞抗原谱

Human leukocyte antigen profile of two ethnic groups in Southeast of Iran.

作者信息

Khazaei Hossein Ali, Rezaei Nima, Aghamohammadi Asghar, Amirzargar Ali Akbar, Ghasemi Khadidjeh, Mirimoghaddam Ibrahim, Nikbin Behrouz

机构信息

Zahedan University of Medical Sciences, Sistan and Balochestan, Iran.

出版信息

Iran J Allergy Asthma Immunol. 2007 Dec;6(4):223-4.

PMID:18094447

Abstract

This study was performed to determine the genetic diversity of HLA class I and II alleles among two ethnic groups in Southeastern Iran. HLA profiles were determined in 71 Iranian populations (41 Zaboli and 30 Baloch). The frequencies of HLA-A02 (p=0.017), -Cw4 (p=0.003), and -DR8 (p=0.025) in the Zaboli populations were significantly higher than that in Baloch ethnic group. In contrast, the frequency of HLA-A23 allele was more frequent in Baloch than Zaboli (p=0.020). This report represents an important resource for investigators in the fields of transplantation immunology and population genetics from widely dispersed areas of Iran.

摘要

本研究旨在确定伊朗东南部两个族群中HLA I类和II类等位基因的遗传多样性。对71名伊朗人群（41名扎博利人和30名俾路支人）进行了HLA分型。扎博利人群中HLA-A02（p=0.017）、-Cw4（p=0.003）和-DR8（p=0.025）的频率显著高于俾路支族群。相反，HLA-A23等位基因在俾路支人中的频率高于扎博利人（p=0.020）。本报告为来自伊朗广泛分布地区的移植免疫学和群体遗传学领域的研究人员提供了重要资源。