Assessment of Human Leukocyte Antigen Differences between Smokers with Reinke's Edema and Those with Laryngeal Cancer.

INTRODUCTION

The present study aimed to assess human leukocyte antigen (HLA) typing differences between smokers with Reinke's edema and those with laryngeal squamous cell carcinoma (SCC).

MATERIALS AND METHODS

The HLA class I, II alleles were examined in 76 unrelated Iranian patients using low-resolution polymerase chain reaction with the sequence-specific primer (PCR-SSP) method.

RESULTS

The frequency of the HLA-A36 allele and HLA-B35 was significantly higher in patients with SCC. The frequency of HLA-DRB101 alleles in Reinke's edema was significantly higher, as compared to that in others. In the volunteer group, HLA-DRB113 and HLA-DRB1*15 were significantly higher.

CONCLUSIONS

As evidenced by the obtained results, HLA-A36 was significantly higher in SCC, as compared to that in volunteers and Reinke's edema patients. It can be concluded that being positive for HLA-A36 increases the chance of SCC by three times. This result should be further investigated in cohort studies conducted on larger samples. Furthermore, HLA-A24 was significantly higher in the volunteer group, as compared to that in other groups. The HLADRB101 was remarkably higher in Reinke's edema, as compared to that in SCC.