Connes Philippe, Tripette Julien, Chalabi Tawfik, Beltan Eric, Etienne-Julan Maryse, Chout Roger, Hue Olivier, Hardy-Dessources Marie-Dominique
Université des Antilles et de la Guyane, Laboratoire ACTES (EA 3596), Département de Physiologie, Campus de Fouillole, 97159 Pointe-à-Pitre, Guadeloupe, French West Indies.
Clin Hemorheol Microcirc. 2008;38(1):13-21.
We compared routine coagulation markers in six sickle cell trait carriers ((SCT, or AS hemoglobinopathy)--the heterozygous form of sickle cell anemia) and six subjects with normal hemoglobin before and after a prolonged and intense exercise. Blood was sampled at rest and at the end of the entire exercise test to measure coagulation markers (prothrombin time, activated partial thromboplastin time, plasma fibrinogen and antithrombin III activity), hematocrit (Hct) and yield stress (tau(y)). Results obtained at the end of exercise were corrected by the percent change in plasma volume. Blood coagulation markers, Hct and tau(y) were not different between the two groups at rest. Exercise did not change prothrombin time, antithrombin III activity and plasma fibrinogen, decreased activated partial thromboplastin time and increased Hct and tau(y) in the two groups. These parameters were not significantly different between the two groups at the end of exercise, except for plasma fibrinogen which was slightly higher in SCT carriers but in the normal range values. The results have been discussed in relation with some cases of exercise-related sudden death in SCT carriers, reported in several studies. Therefore our results show that the increased risk for clinical complications in certain SCT carriers during exercise seems to be unrelated to higher blood coagulation activity.
我们比较了6名镰状细胞性状携带者（SCT，即AS血红蛋白病——镰状细胞贫血的杂合形式）和6名血红蛋白正常的受试者在长时间剧烈运动前后的常规凝血指标。在静息状态和整个运动试验结束时采集血液，以测量凝血指标（凝血酶原时间、活化部分凝血活酶时间、血浆纤维蛋白原和抗凝血酶III活性）、血细胞比容（Hct）和屈服应力（tau(y)）。运动结束时获得的结果通过血浆容量的变化百分比进行校正。两组在静息状态下的凝血指标、Hct和tau(y)没有差异。运动并未改变两组的凝血酶原时间、抗凝血酶III活性和血浆纤维蛋白原，缩短了活化部分凝血活酶时间，增加了Hct和tau(y)。运动结束时，除了SCT携带者的血浆纤维蛋白原略高但在正常范围内外，两组之间的这些参数没有显著差异。结合多项研究报道的SCT携带者与运动相关的猝死病例，对这些结果进行了讨论。因此，我们的结果表明，某些SCT携带者在运动期间临床并发症风险增加似乎与较高的凝血活性无关。
