用于高通量有机化学的自动化流动氢化仪器的构建与验证

Construction and validation of an automated flow hydrogenation instrument for application in high-throughput organic chemistry.

作者信息

Clapham Bruce, Wilson Noel S, Michmerhuizen Melissa J, Blanchard David P, Dingle David M, Nemcek Thomas A, Pan Jeffrey Y, Sauer Daryl R

机构信息

High-Throughput Organic Synthesis and Automation Engineering, Department of Advanced Technology, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois 60064, USA.

出版信息

J Comb Chem. 2008 Jan-Feb;10(1):88-93. doi: 10.1021/cc700178a. Epub 2007 Dec 21.

DOI:10.1021/cc700178a

PMID:18095655

Abstract

This manuscript details the construction of a fully automated flow hydrogenation apparatus for use in high-throughput organic synthesis. The instrument comprises of a Bohdan robot platform coupled with a ThalesNano H-cube hydrogenator and a series of solvent valves and pumping mechanisms. Using this instrument, we have been able to fully automate a number of key transformations that could not otherwise be conveniently undertaken in a high-throughput manner.

摘要

本手稿详细介绍了一种用于高通量有机合成的全自动流动氢化装置的构建。该仪器由一个Bohdan机器人平台、一个ThalesNano H-cube氢化器以及一系列溶剂阀和泵送机构组成。使用该仪器，我们能够实现一些关键转化的完全自动化，而这些转化若不借助该仪器则无法以高通量方式便捷地进行。