Somaratne Jithendra B, Whalley Gillian A, Bagg Warwick, Doughty Robert N
The University of Auckland, Department of Medicine, School of Medicine, Faculty of Medical and Health Sciences, Private Bag 92 019, Auckland, New Zealand.
Expert Rev Cardiovasc Ther. 2008 Jan;6(1):109-25. doi: 10.1586/14779072.6.1.109.
Cardiovascular disease is the leading cause of death among patients with Type 2 diabetes mellitus. The main forms of structural heart disease associated with diabetes are coronary heart disease and diabetic cardiomyopathy, which is characterized by left ventricular hypertrophy, left ventricular diastolic and systolic dysfunction. Asymptomatic structural heart disease is common and associated with a poor prognosis in patients with diabetes. Contemporary practice guidelines do not recommend screening of asymptomatic individuals for structural heart disease. Potential screening modalities, such as echocardiography, are costly and inaccessible. A simple, inexpensive blood test for brain natriuretic peptide is a useful marker of structural heart disease and is a prime candidate for screening patients with Type 2 diabetes mellitus and prioritizing referral for echocardiography.
心血管疾病是2型糖尿病患者死亡的主要原因。与糖尿病相关的结构性心脏病的主要形式是冠心病和糖尿病性心肌病，其特征是左心室肥厚、左心室舒张和收缩功能障碍。无症状性结构性心脏病在糖尿病患者中很常见，且与预后不良相关。当代实践指南不建议对无症状个体进行结构性心脏病筛查。潜在的筛查方式，如超声心动图，成本高昂且难以获得。一种简单、廉价的检测脑钠肽的血液检测是结构性心脏病的有用标志物，是筛查2型糖尿病患者并优先转诊进行超声心动图检查的主要候选方法。
