[The prediction of the membrane-damaging action of chemical substances in experiments on bacteria].

Comparative study of the cytoplasmic membrane sensitivity in procaryotic cells (E. coli) and eucaryotic cells (rat red blood cells) to bis-quaternary ammonea compounds and diatomic aliphatic alcohols was carried out. Comparative study of the membrane permeability demonstrated, that E. coli is more sensitive for these xenobiotics. Cells of E. coli recommended as a biotest-object for the membrane tropic toxic reactions to study.