Shultz Jacqueline C, Chalfant Charles E
Department of Biochemistry, Virginia Commonwealth University School of Medicine, Richmond, VA 23298-0614, USA.
Chem Biol. 2007 Dec;14(12):1313-4. doi: 10.1016/j.chembiol.2007.12.002.
Interference with the alternative splicing of apoptotic factors offers an innovative and specific mechanism to target malignant cells. In this issue of Chemistry & Biology, Zhou et al. report on the regulation of the alternative splicing of Bcl-x pre-mRNA in response to emetine, a potent protein synthesis inhibitor, as well as define a major player in the signaling mechanism.
干扰凋亡因子的可变剪接为靶向恶性细胞提供了一种创新且特异的机制。在本期《化学生物学》中，周等人报道了在强效蛋白质合成抑制剂依米丁作用下Bcl-x前体mRNA可变剪接的调控情况，并确定了信号传导机制中的一个主要参与者。
