Berhouma Moncef, Jemel Hafedh, Ksira Iadh, Khaldi Moncef
Department of Neurosurgery, National Institute of Neurology, Tunis, Tunisia.
Pediatr Neurosurg. 2008;44(1):52-4. doi: 10.1159/000110663. Epub 2007 Dec 14.
Intracranial teratomas are rare germ cell neoplasms occurring more often during childhood. We report the case of a huge mature teratoma of the pineal region in a 10-year-old patient that was not correctly diagnosed preoperatively by stereotactic biopsy. The tumor was revealed by intracranial hypertension and a Parinaud syndrome. The tumor markers were within normal levels in the serum. A left transcortical parietal approach was used to completely resect the tumor. No adjuvant treatment was given. A complete neurological recovery was observed after the surgical procedure. Follow-up at 2 years did not show any recurrence. Pineal mature teratomas have a good prognosis, in contrast to their immature or mixed counterparts. A rigorous histological examination of the tumor samples is mandatory, in order to not omit a mixed contingent within the tumor. The treatment is exclusively surgical.
颅内畸胎瘤是罕见的生殖细胞肿瘤，多见于儿童期。我们报告了一例10岁患者松果体区巨大成熟畸胎瘤的病例，该肿瘤术前经立体定向活检未能正确诊断。该肿瘤由颅内高压和帕里诺德综合征发现。血清肿瘤标志物水平正常。采用左侧经皮质顶叶入路完全切除肿瘤。未给予辅助治疗。手术后观察到神经功能完全恢复。2年随访未显示任何复发。与未成熟或混合性畸胎瘤不同，松果体成熟畸胎瘤预后良好。为了不遗漏肿瘤内的混合成分，对肿瘤样本进行严格的组织学检查是必要的。治疗仅为手术治疗。
