4087名日本受试者中TCF7L2基因多态性与2型糖尿病易感性的关联
Association of TCF7L2 polymorphisms with susceptibility to type 2 diabetes in 4,087 Japanese subjects.
作者信息
Miyake Kazuaki, Horikawa Yukio, Hara Kazuo, Yasuda Kazuki, Osawa Haruhiko, Furuta Hiroto, Hirota Yushi, Yamagata Kazuya, Hinokio Yoshinori, Oka Yoshitomo, Iwasaki Naoko, Iwamoto Yasuhiko, Yamada Yuichiro, Seino Yutaka, Maegawa Hiroshi, Kashiwagi Atsunori, Yamamoto Ken, Tokunaga Katsushi, Takeda Jun, Makino Hideichi, Nanjo Kishio, Kadowaki Takashi, Kasuga Masato
机构信息
Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.
Department of Diabetes and Endocrinology Division of Molecule and Structure, Gifu University School of Medicine, Gifu, Japan.
出版信息
J Hum Genet. 2008;53(2):174-180. doi: 10.1007/s10038-007-0231-5. Epub 2007 Dec 21.
Transcription factor 7-like 2 (TCF7L2) has been shown to be associated with type 2 diabetes mellitus in multiple ethnic groups. Regarding the Asian population, Horikoshi et al. (Diabetologia 50:747-751, 2007) and Hayashi et al. (Diabetologia 50:980-984, 2007) reported that single nucleotide polymorphisms (SNPs) in TCF7L2 were associated with type 2 diabetes in the Japanese population, while contradictory results were reported for Han Chinese populations. The aim of this study was to investigate the associations of the TCF7L2 gene with type 2 diabetes using a relatively large sample size: 2,214 Japanese individuals with type 2 diabetes and 1,873 normal controls. The minor alleles of rs7903146, rs11196205, and rs12255372 showed significant associations with type 2 diabetes (OR=1.48, P=2.7 x 10(-4); OR=1.39, P=4.6 x 10(-4); OR=1.70, P=9.8 x 10(-5), respectively) in the combined sample sets. However, neither rs11196218 nor rs290487 showed a significant association. These results indicate that TCF7L2 is an important susceptibility gene for type 2 diabetes in the Japanese population.
转录因子7样2（TCF7L2）已被证明在多个种族群体中与2型糖尿病相关。关于亚洲人群，堀越等人（《糖尿病学》50:747 - 751，2007年）和林等人（《糖尿病学》50:980 - 984，2007年）报道，TCF7L2中的单核苷酸多态性（SNP）与日本人群中的2型糖尿病相关，而对于汉族人群则报道了相互矛盾的结果。本研究的目的是使用相对较大的样本量来研究TCF7L2基因与2型糖尿病的关联：2214名日本2型糖尿病患者和1873名正常对照。在合并样本集中，rs7903146、rs11196205和rs12255372的次要等位基因与2型糖尿病显示出显著关联（OR = 1.48，P = 2.7×10⁻⁴；OR = 1.39，P = 4.6×10⁻⁴；OR = 1.70，P = 9.8×10⁻⁵）。然而，rs11196218和rs290487均未显示出显著关联。这些结果表明，TCF7L2是日本人群中2型糖尿病的一个重要易感基因。
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