Rumyantseva G M, Stepanov A L
V. P. Serbskii State Scientific Center of Social and Forensic Psychiatry, Moscow.
Neurosci Behav Physiol. 2008 Jan;38(1):55-61. doi: 10.1007/s11055-008-0008-0.
Two types of stress situation were compared: involvement in combat actions and working in the post-Chernobyl atomic energy station clean-up. A total of 30 subjects involved in combat actions (combatants) and 33 clean-up workers were observed for 5-6 years and 15-17 years after involvement in stress situations. Mean ages in the two groups were 27.0 +/- 2.8 and 43.7 +/- 4.5 years respectively. Clinical features were analyzed in terms of the major criteria of post-traumatic stress disorder (PTSD) - "immersion" in the experience, "avoidance," "hyperexcitability," and "social functioning." There were both common features in the two groups of subjects as well as individual characteristics dependent on the nature of the stress. Patients were treated with Coaxil at a dose of 37.5 mg/day for four weeks. In both groups of patients, Coaxil had the most favorable effects on immersion and hyperexcitability, which improved social adaptation. The "avoidance" symptom was more resistant. These studies lead to the conclusion that Coaxil is an effective agent for the treatment of different types of PTSD.
参与战斗行动和在切尔诺贝利核电站事故后清理工作中工作。对总共30名参与战斗行动的受试者（战斗人员）和33名清理工人在经历应激情况后的5至6年和15至17年进行了观察。两组的平均年龄分别为27.0±2.8岁和43.7±4.5岁。根据创伤后应激障碍（PTSD）的主要标准——对经历的“沉浸”、“回避”、“过度兴奋”和“社会功能”——对临床特征进行了分析。两组受试者既有共同特征，也有取决于应激性质的个体特征。患者接受了为期四周、剂量为37.5毫克/天的可克西平治疗。在两组患者中，可克西平对沉浸感和过度兴奋有最有利的影响，改善了社会适应能力。“回避”症状更具抗性。这些研究得出结论，可克西平是治疗不同类型PTSD的有效药物。
