Kapadia Chhanda J, Mane Vidya B
Bombay College of Pharmacy, Kalina, Santacruz (E), Mumbai, India.
Drug Dev Ind Pharm. 2007 Dec;33(12):1350-61. doi: 10.1080/03639040701385691.
Gastroesophageal reflux disease (GERD) is caused by excessive reflux of gastric content and duodenal bile into the esophagus, and impaired clearance of refluxate from the esophagus. In this perspective, raft-forming antireflux formulations offer better alternatives to the conventional therapies for treatment of uncomplicated GERD. In addition to the alginate-based systems, various natural polysaccharides have generated interest as raft-forming agents because of their bioadhesive/mucoprotective nature. Inclination of current therapy is towards natural products for healing of the disease, which also underlines the market potential of this class, demanding for thorough investigation and development of evaluation methods with better in vitro-in vivo correlation.
胃食管反流病（GERD）是由胃内容物和十二指肠胆汁过度反流至食管，以及食管对反流物的清除功能受损所致。从这个角度来看，形成筏状的抗反流制剂为治疗单纯性GERD的传统疗法提供了更好的替代方案。除了基于藻酸盐的系统外，各种天然多糖因其生物粘附/粘膜保护特性而作为形成筏状的试剂引起了人们的兴趣。当前治疗倾向于使用天然产物来治愈该疾病，这也凸显了此类产品的市场潜力，需要对具有更好体外-体内相关性的评估方法进行深入研究和开发。
