Oka Y, Murata A, Nishijima J, Hiraoka N, Yasuda T, Kitagawa K, Ogawa M, Mori T
Second Department of Surgery, Osaka University Medical School, Japan.
J Med. 1991;22(6):371-82.
We measured the enzymatic and immunologic activities of neutrophil elastase to determine whether pentoxifylline and prostaglandin E1 are useful for inhibiting the enzymatic activity of released neutrophil elastase. Both activities in the medium decrease in the presence of pentoxifylline and prostaglandin E1. These results showed that pentoxifylline and prostaglandin E1 inhibited the release of neutrophil elastase from activated neutrophils, and that they may be useful in the improvement of neutrophil-mediated cellular injury.
我们测量了中性粒细胞弹性蛋白酶的酶活性和免疫活性，以确定己酮可可碱和前列腺素E1是否有助于抑制释放的中性粒细胞弹性蛋白酶的酶活性。在己酮可可碱和前列腺素E1存在的情况下，培养基中的这两种活性均降低。这些结果表明，己酮可可碱和前列腺素E1可抑制活化的中性粒细胞释放中性粒细胞弹性蛋白酶，并且它们可能有助于改善中性粒细胞介导的细胞损伤。
