Lingohr P, Knoefel W T, Kleimann E, Rheinwalt K P
Abteilung für Allgemein- und Viszeralchirurgie, Zentrum für Minimalinvasive Chirurgie, St. Franziskus Hospital, Köln.
Zentralbl Chir. 2007 Dec;132(6):564-8. doi: 10.1055/s-2007-981363.
The case-study reminds of adenocarcinoma of the small intestine as a rare complication of Crohn's disease. A few more than 100 of these cases have been published. Epidemiological studies concerning small bowel carcinoma showed consumption of sugar and carbohydrates as pathogenetic factors, other conditions like ileostoma, ileumconduit, Crohn's disease and coeliac disease have been identified to some extent. An adenoma-carcinoma sequence as in large intestine carcinoma has been discussed. Immunohistochemical and oncogenetic findings failed to demonstrate any result of practical clinical value. Diagnosis of early stages of adenocarcinoma of the small intestine is very difficult and thus might be impossible to differentiate from exacerbation or progressive stenosis of preexisting Crohn's disease. If non-invasive diagnostic measures (ultrasound, small bowel enema, CT-scan, intestinoscopy, radiography, NMR-Sellink, capsule-endoscopy) fail to clear the situation a diagnostic laparoscopy or even laparotomy should not be delayed. This constitutes the only chance to discover early stages which can possibly be cured in accordance with oncosurgical principles. Otherwise the prognosis remains poor with a high percentage of late stages and a 5-year-survival-rate between 20 and 50 percent.
该病例研究让人联想到小肠腺癌是克罗恩病的一种罕见并发症。已发表的此类病例略多于100例。关于小肠癌的流行病学研究表明,糖和碳水化合物的摄入是致病因素,在一定程度上还确定了其他一些情况,如回肠造口术、回肠导管、克罗恩病和乳糜泻。有人讨论了与大肠癌类似的腺瘤-癌序列。免疫组化和肿瘤遗传学研究结果未能显示出任何具有实际临床价值的结果。小肠腺癌早期的诊断非常困难,因此可能无法与既往克罗恩病的加重或进行性狭窄相鉴别。如果非侵入性诊断措施(超声、小肠灌肠、CT扫描、肠镜检查、X线摄影、核磁共振成像、胶囊内镜)无法明确情况,不应延迟进行诊断性腹腔镜检查甚至剖腹手术。这是发现可能根据肿瘤外科原则治愈的早期阶段的唯一机会。否则,预后仍然很差,晚期比例很高,5年生存率在20%至50%之间。