Fresko D, Lazarus S S, Dotan J, Reingold M
Gastroenterology. 1982 Apr;82(4):783-9.
We report here 3 cases of adenocarcinoma of the small bowel complicating Crohn's disease ("Crohn's carcinoma"). In 2 cases, the adenocarcinoma was discovered in the first attack of enteritis. In only one other case in the literature, a similar presentation was described. A review of 59 reported cases of adenocarcinoma of small bowel in Crohn's disease, together with these 3 cases reveals that: (a) the cancer develops at a younger age than in carcinoma de novo; (b) there is no difference in incidence of carcinoma in the first, second, and third decades after the onset of symptoms of Crohn's disease; (c) in 73% of cases, the neoplasm rose in the ileum; (d) in all but 1 case it developed in inflamed segments of bowel; (e) in 31% of cases the cancer developed in a bypassed segment of bowel. This analysis clearly demonstrates that "Crohn's carcinoma" is a complication in Crohn's disease and not a chance coexistence of two diseases in the same patient.
我们在此报告3例小肠腺癌并发克罗恩病（“克罗恩癌”）的病例。其中2例腺癌在肠炎首次发作时被发现。文献中仅有另一例有类似描述。对59例报道的克罗恩病合并小肠腺癌病例以及这3例病例进行回顾后发现：（a）与原发性癌相比，该癌症发病年龄更小；（b）在克罗恩病症状出现后的第一个、第二个和第三个十年中，癌症发病率无差异；（c）73%的病例肿瘤发生在回肠；（d）除1例病例外，所有病例均发生在肠道炎症部位；（e）31%的病例癌症发生在肠道旁路部位。该分析清楚地表明，“克罗恩癌”是克罗恩病的一种并发症，而非同一患者中两种疾病的偶然并存。
