两种苯并呋喃-咪唑类化合物在不同实验条件下的抗真菌活性
Antifungal activity of two benzofuran-imidazoles in different experimental conditions.
作者信息
Bellotti M G, Dubini F, Riviera L, Pestellini V
机构信息
Institute of Medical Microbiology, University of Milan, Italy.
出版信息
J Chemother. 1991 Oct;3(5):295-304. doi: 10.1080/1120009x.1991.11739109.
A number of experiments was performed in order to analyze the in vitro activity of two new benzofuran-imidazoles, IM/B/4-62 and IM/B/4-66. Studies included the determination of minimum inhibitory concentrations (MICs) on three culture media, at different pH values and at different inoculum sizes. Furthermore, the killing activity and induced resistance were determined. In all the experiments econazole, clotrimazole and bifonazole were the reference compounds. The best MIC values of the two new imidazoles were observed on modified Sabouraud's medium, at neutral pH and an inoculum size of 10(4) cells/ml. The two substances showed killing activity and no resistance was observed. On the whole, the more favorable results were obtained with the compound IM/B/4-66.
为分析两种新型苯并呋喃 - 咪唑类化合物IM/B/4 - 62和IM/B/4 - 66的体外活性，进行了多项实验。研究包括在三种培养基上、不同pH值和不同接种量下测定最低抑菌浓度（MIC）。此外，还测定了杀菌活性和诱导抗性。在所有实验中，益康唑、克霉唑和联苯苄唑作为参考化合物。在改良的沙氏培养基上，中性pH值和接种量为10⁴个细胞/ml时，观察到这两种新型咪唑类化合物的最佳MIC值。这两种物质显示出杀菌活性，未观察到抗性。总体而言，化合物IM/B/4 - 66获得了更有利的结果。
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