Gil Ziv, Orr-Urtreger Avi, Voskoboinik Nadia, Trejo-Leider Leonor, Shomrat Ruth, Fliss Dan M
Department of Otolaryngology-Head and Neck Surgery, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
Head Neck. 2008 May;30(5):567-81. doi: 10.1002/hed.20741.
Skull base tumors are rare neoplasms and the cytogenetic data on these tumors are limited. The authors cytogenetically analyzed a large series of tumors and compared the findings with patients' pathologic data.
The karyotypes of pathologically confirmed samples of 101 patients, who were operated for oncological extirpation of tumors, were analyzed using G-banding and spectral-karyotyping techniques.
Of the 67 malignant tumors, 32 (48%) had chromosomal aberrations, some with complex numerical and structural chromosomal anomalies. Recurrent chromosomal breakpoints were identified in squamous cell carcinomas, adenoid cystic carcinomas (ACCs), sinonasal undifferentiated carcinomas, chordomas, and sarcomas. Specific breakpoints established the diagnosis of various soft tissue sarcomas. Novel chromosomal aberrations were found in various other malignant and benign tumors.
This study highlights the value of cytogenetic analysis for diagnosis of skull base tumors. The data add further information on the biological behavior of these rare neoplasms.
颅底肿瘤是罕见肿瘤，关于这些肿瘤的细胞遗传学数据有限。作者对一大系列肿瘤进行了细胞遗传学分析，并将结果与患者的病理数据进行了比较。
使用G显带和光谱核型分析技术，对101例因肿瘤切除手术而病理确诊的样本的核型进行了分析。
在67例恶性肿瘤中，32例（48%）存在染色体异常，其中一些伴有复杂的染色体数目和结构异常。在鳞状细胞癌、腺样囊性癌（ACC）、鼻窦未分化癌、脊索瘤和肉瘤中发现了反复出现的染色体断点。特定的断点有助于诊断各种软组织肉瘤。在其他各种恶性和良性肿瘤中发现了新的染色体异常。
本研究突出了细胞遗传学分析对颅底肿瘤诊断的价值。这些数据为这些罕见肿瘤的生物学行为提供了更多信息。
