Seĭsenbanov A Sh, Balabanova R M
Ter Arkh. 1991;63(11):125-8.
The clinical and immunological parameters were compared over time in 125 patients with rheumatoid arthritis subjected to immunocorrection. As a result of the study the drugs and their combinations used are distributed in the following order as regards their efficacy: combined treatment with prospidin and tactivin; prospidin; immunoglobulin therapy with high doses; combined therapy with thymohexin and immunoglobulin (low doses); thymohexin; prodigiosan; immunoglobulin (low doses). The dynamics of cellular immunity did not always correlate with the clinical efficacy of the immunocorrection. No relationship was discovered between the functional activity of natural killers and peripheral macrophages and the dynamics of the clinico-laboratory characteristics. Stimulation of endogenous and con A-induced suppression provided a therapeutic effect only in cases of the induction of both suppression types whereas the combined use of prospidin and tactivin allowed the reduction of the intensity and rate of side effects and maintained functions of peripheral macrophages. Immunocorrection which enabled the decrease of the level of lymphocytes expressing HLA-DR antigens in blood turned out most effective.
对125例接受免疫纠正治疗的类风湿关节炎患者的临床和免疫学参数进行了长期比较。研究结果表明，就疗效而言，所使用的药物及其组合按以下顺序排列：丙种球蛋白与胸腺激活素联合治疗；丙种球蛋白；高剂量免疫球蛋白疗法；胸腺五肽与免疫球蛋白（低剂量）联合治疗；胸腺五肽；灵菌素；免疫球蛋白（低剂量）。细胞免疫的动态变化并不总是与免疫纠正的临床疗效相关。未发现自然杀伤细胞和外周巨噬细胞的功能活性与临床实验室特征的动态变化之间存在关联。仅在诱导两种抑制类型的情况下，内源性刺激和刀豆蛋白A诱导的抑制才产生治疗效果，而丙种球蛋白和胸腺激活素的联合使用可降低副作用的强度和发生率，并维持外周巨噬细胞的功能。能够降低血液中表达HLA-DR抗原的淋巴细胞水平的免疫纠正最为有效。
