Dullens H F, De Wit C L
Instituut voor Pathologie, Academisch Ziekenhuis, Utrecht, The Netherlands.
In Vivo. 1991 Nov-Dec;5(6):567-70.
During the last few years the anticancer effects of recombinant cytokines has been studied in animal experiments and in clinical trials. Significant anticancer effects of especially, interleukin-2 (IL-2) and interferon alpha (IFN alpha) have been obtained. In this paper, we shall focus on the studies and possible applications of interleukin 1 (IL-1), interleukin 4 (IL-4), interleukin 6 (IL-6) as single agents and focus on some combinations of cytokines. Finally, we shall discuss future developments that can be expected.
在过去几年中，重组细胞因子的抗癌作用已在动物实验和临床试验中得到研究。特别是白细胞介素-2（IL-2）和干扰素α（IFNα）已取得显著的抗癌效果。在本文中，我们将重点关注白细胞介素1（IL-1）、白细胞介素4（IL-4）、白细胞介素6（IL-6）作为单一药物的研究及可能的应用，并关注细胞因子的一些联合应用。最后，我们将讨论预期的未来发展。
