Prikhozhan A V, Narkevich V B, Raevskiĭ K S
Biull Eksp Biol Med. 1991 Nov;112(11):492-4.
Captopril, as well as amitriptyline, was shown to enhance apomorphine-induced stereotype in mice. At doses, which failed to modify the effect of apomorphine, both substances reversed the inhibitory action of sulpiride and haloperidol on stereotypical behaviour. Treatment with captopril (25 mg/kg) did not modify the open-field behaviour, but significantly reduced the immobility in the forced swim test (20 mg/kg) Dopaminergic link was suggested to be involved in the CNS effect of captopril.
卡托普利以及阿米替林被证明可增强阿扑吗啡诱导的小鼠刻板行为。在未能改变阿扑吗啡作用的剂量下，这两种物质均能逆转舒必利和氟哌啶醇对刻板行为的抑制作用。卡托普利（25毫克/千克）治疗并未改变旷场行为，但显著减少了强迫游泳试验中的不动时间（20毫克/千克）。提示多巴胺能环节参与了卡托普利的中枢神经系统效应。
