Nazareth W, Yafei N, Crompton M
Department of Biochemistry and Molecular Biology, University College London, UK.
J Mol Cell Cardiol. 1991 Dec;23(12):1351-4. doi: 10.1016/0022-2828(91)90181-k.
Cyclosporin A is a potent immunosuppressant used to prevent graft rejection. The cellular target of cyclosporin A in T lymphocytes is believed to be cyclophilin, a ubiquitous protein with peptidyl prolyl cis trans isomerase activity located in both the cytosol and mitochondria. Recently, cyclosporin A-inhibition of mitochondrial cyclophilin has been implicated in the prevention of mitochondrial dysfunction induced in vitro by Ca2+ overload and other factors potentially relevant to ischaemic cell injury. This study investigates the effect of cyclosporin A on injury to cardiomyocytes induced by substrate-free anoxia. It is shown that cyclosporin A retards progression of the injury, most probably at a late step in the injury process.
环孢素A是一种强效免疫抑制剂，用于预防移植排斥反应。环孢素A在T淋巴细胞中的细胞靶点被认为是亲环蛋白，这是一种普遍存在的蛋白质，具有肽基脯氨酰顺反异构酶活性，存在于细胞质和线粒体中。最近，环孢素A对线粒体亲环蛋白的抑制作用与预防体外由Ca2+超载和其他可能与缺血性细胞损伤相关的因素诱导的线粒体功能障碍有关。本研究调查了环孢素A对无底物缺氧诱导的心肌细胞损伤的影响。结果表明，环孢素A延缓了损伤的进展，很可能是在损伤过程的后期阶段。
