DeLellis R A, Gagel R F, Kaplan M M, Curtis L E
Cancer. 1976 Jul;38(1):201-8. doi: 10.1002/1097-0142(197607)38:1<201::aid-cncr2820380131>3.0.co;2-m.
A 65-year-old man with hypergastrinemia associated with the Zollinger-Ellison syndrome was found to have a duodenal "carcinoid-islet cell tumor." Gastrin levels have remained normal for more than 1 year following total gastrectomy and removal of the duodenal tumor. Immunohistochemical studies for gastrin localization revealed positive staining of the tumor and of a population of nonneoplastic G-cells in the adjacent duodenal mucosa and Brunner's glands. These results support the hypothesis that gastrinomas may arise as primary tumors from duodenal G-cells rather than from ectopic pancreatic tissue. "Carcinoidislet cell tumors," like other tumors of APUD-cell origin, may express dual biochemical functions in the form of polypeptide hormone and/or amine secretion. Their content of specific hormonal products may be predicted on the basis of sensitive histochemical and immunohistochemical techniques.
一名65岁患有与卓-艾综合征相关的高胃泌素血症的男性被发现患有十二指肠“类癌-胰岛细胞瘤”。在全胃切除及十二指肠肿瘤切除后，胃泌素水平已保持正常超过1年。胃泌素定位的免疫组织化学研究显示肿瘤以及相邻十二指肠黏膜和布伦纳腺中的一群非肿瘤性G细胞呈阳性染色。这些结果支持以下假说，即胃泌素瘤可能作为原发性肿瘤起源于十二指肠G细胞而非异位胰腺组织。“类癌-胰岛细胞瘤”与其他APUD细胞起源的肿瘤一样，可能以多肽激素分泌和/或胺分泌的形式表达双重生化功能。它们特定激素产物的含量可基于灵敏的组织化学和免疫组织化学技术进行预测。
