Balabanova S, Weidmann M
Institut für Rechtsmedizin, Universität Ulm, Donau.
Beitr Gerichtl Med. 1991;49:95-101.
This study investigated the deposition of methadone in blood, liquor, urine and organ tissues, obtained from sheep after daily administration of methadone during 23 days. One sheep was killed two hours after methadone application, one sheep after 24 hours without methadone, and one sheep after seven days without methadone. The methadone determination was performed by radioimmunoassay. The concentrations measured represent the sum of methadone and its metabolites expressed in methadone equivalent/ml or g, respectively. The highest methadone levels were found in blood and liquor in the first 30 minutes. After seven days without methadone in blood, liquor and urine was methadone not more found. Only in the synovial fluid and vitreous humor measurable methadone levels were present.
本研究调查了在23天内每日给绵羊施用美沙酮后，美沙酮在血液、脑脊液、尿液和器官组织中的沉积情况。在施用美沙酮两小时后处死一只绵羊，在停止使用美沙酮24小时后处死一只绵羊，在停止使用美沙酮七天后处死一只绵羊。采用放射免疫分析法测定美沙酮。所测浓度分别表示以美沙酮当量/毫升或克为单位的美沙酮及其代谢物的总和。在最初30分钟内，血液和脑脊液中的美沙酮水平最高。在血液、脑脊液和尿液中停止使用美沙酮七天后，不再检测到美沙酮。仅在滑液和玻璃体液中存在可测量的美沙酮水平。
