Suga M, Arima K, Yachi A
Department of Internal Medicine (Section 1), Sapporo Medical College, Japan.
Digestion. 1991;50(3-4):153-61. doi: 10.1159/000200756.
Antibodies to the preS2 antigen (anti-preS2) of the hepatitis B virus (HBV), including IgA, IgM and IgG classes, were observed in patients with acute and persistent HBV infection. In acute HBV infection, rapid and marked serum IgM and IgA anti-preS2 responses were observed. Antibodies reached a peak of serum activity at about 1-2 months after the onset of clinical symptoms, and both antibodies disappeared from serum at 4 months after. IgG anti-preS2 was detected in the early phase of the illness, then the level of IgG anti-preS2 gradually rose during the recovery phase. In persistent HBV infection, IgG and IgM anti-preS2 were detected in sera where the preS2 antigen was present, and IgM anti-preS2 was significantly higher (p less than 0.05) in HBeAg-positive than in HBeAg-negative patients. These results indicate that an adequate humoral immune response to the preS2 antigen is induced during acute and persistent HBV infection.
在急性和持续性乙型肝炎病毒（HBV）感染患者中观察到了针对HBV前S2抗原的抗体（抗前S2），包括IgA、IgM和IgG类。在急性HBV感染中，观察到血清IgM和IgA抗前S2反应迅速且显著。抗体在临床症状出现后约1至2个月达到血清活性峰值，且两种抗体在4个月后从血清中消失。IgG抗前S2在疾病早期被检测到，然后在恢复阶段IgG抗前S2水平逐渐升高。在持续性HBV感染中，在存在前S2抗原的血清中检测到IgG和IgM抗前S2，且HBeAg阳性患者的IgM抗前S2显著高于（p<0.05）HBeAg阴性患者。这些结果表明，在急性和持续性HBV感染期间诱导了对前S2抗原的充分体液免疫反应。
